130306-61-5

Basic information

• Product Name: 2-(dimethylamino)-4-{4-nitrophenyl}-1,3-thiazole
• Synonyms: 2-(dimethylamino)-4-{4-nitrophenyl}-1,3-thiazole
• CAS NO: 130306-61-5
• Molecular Formula: C₁₁H₁₁N₃O₂S
• Molecular Weight: 249.28894
• Mol File: 130306-61-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(dimethylamino)-4-{4-nitrophenyl}-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(dimethylamino)-4-{4-nitrophenyl}-1,3-thiazole(130306-61-5)
• EPA Substance Registry System: 2-(dimethylamino)-4-{4-nitrophenyl}-1,3-thiazole(130306-61-5)

Safety Data

• Hazardous Substances Data: 130306-61-5(Hazardous Substances Data)

Upstream product

• 6972-05-0 1,1-dimethyl-2-thiourea 
• 99-81-0 4-Nitrophenacyl bromide 
• 90004-93-6 2-bromo-4-nitroacetophenone 
• 534-13-4 N,N-dimethylthiourea 

Relevant articles and documents

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Electrophilic Substitution at C(5) of 2-Dimethylaminothiazoles

The reactivity of a series of 4-substituted 2-dimethylaminothiazoles towards electrophiles has been examined.Acetic anhydride reacts only slowly with these thiazoles, with trichloroacetyl chloride and trifluoroacetic anhydride substitution at C(5) occurs readily.The rate of trichloroacetylation is influenced, but not to a marked extent, by changing the 4-substituent.In the presence of acid the thiazoles are deuteriated at C(5), and this reaction is much more sensitive to the nature of the 4 substituents.Estimated p Ka values of the thiazoles were used in evaluating rate constants which although only approximate, provide quantitative information about the effect of particular substituents.