Highly stereoselective synthesis of 2′-deoxy-β-ribonucleosides via a 3′-(N-acetyl)-glycyl-directing group
A facile synthesis of 2′-deoxy-β-ribonucleosides from 3′-O-(N-acetyl)-glycyl-protected 2′-deoxyribofuranose has been developed. The coupling reactions between the protected 2′-deoxyribose and silylated bases exhibited β-selectivity up to 98% presumably vi
An asymmetric approach to 2-deoxynucleosides via organosulfur building blocks as chemical chameleons
An asymmetric synthesis of 6-N-benzoyl-5'-O-benzyl-2'-deoxyadenosine and its α anomer from non-carbohydrate building blocks is achieved in 7 steps.The sequence builds the basic structures using bis(methylthio)methane and methylthiomethyl phenyl sulfone as
Trost, Barry M.,Nuebling, Christoph
p. 1 - 12
(2007/10/02)
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