130473-26-6

Basic information

• Product Name: 1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI)
• Synonyms: 1H-Pyrrolo[2,3-C]pyridine-5-carbaldehyde;1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde;1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI)
• CAS NO: 130473-26-6
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.14604
• Product Categories: ALDEHYDE;PYRIDINE
• Mol File: 130473-26-6.mol

Chemical Properties

• Boiling Point: 353.864 °C at 760 mmHg
• Flash Point: 171.762 °C
• Appearance: /
• Density: 1.369 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.80±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI)(130473-26-6)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI)(130473-26-6)

Safety Data

• Hazardous Substances Data: 130473-26-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI) is used as a key intermediate in organic synthesis for the creation of complex organic molecules. Its reactivity and structural features facilitate the synthesis of a variety of compounds with potential applications in different fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI) is utilized as a building block for the development of pharmaceutical drugs. Its unique structure allows for the design of novel drug candidates with potential therapeutic properties.
Used in Drug Discovery:
1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI) is employed as a starting material in drug discovery processes. Its ability to form diverse chemical entities makes it a valuable component in the search for new and effective medications.
Used in Agrochemicals:
In agricultural chemistry, 1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI) is used as a component in the development of agrochemicals. Its versatility in forming complex molecules contributes to the creation of new compounds with potential applications in crop protection and enhancement of agricultural productivity.
Used in Chemical Research:
1H-Pyrrolo[2,3-c]pyridine-5-carboxaldehyde (9CI) is also used in chemical research to explore its properties and potential reactions, contributing to the advancement of knowledge in organic and medicinal chemistry.

Upstream product

• 119694-70-1 2-(1,3-dioxolan-2-yl)-4-methyl-5-nitropyridine 
• 5832-38-2 4-methyl-5-nitropyridine-2-carboxaldehyde 
• 108-47-4 2,4-lutidine 
• 130473-24-4 5-(1,3-Dioxolan-2-yl)-1H-pyrrolo<2,3-c>pyridine 

Downstream Products

• 130473-20-0 2-[(1H-Pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-benzoic acid 
• 130473-27-7 1H-Pyrrolo<2,3-c>pyridine-5-carboxylic acid 

Relevant articles and documents

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5- carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been identified as a potential treatment of cognitive deficits in schizophrenia. Compound 14 is a potent and selective a7 nAChR agonist with an excellent in vitro profile. The compound is characterized by rapid brain penetration and high oral bioavailability in rat and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.

COMPOUNDS HAVING BOTH α7 NICOTINIC AGONIST ACTIVITY AND 5HT3 ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES

The invention discloses compounds that are selective α7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases.

Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease

The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which α7 is known to be involved.

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease

The invention provides compounds of Formula I: which may be in the form of pharmaceutical acceptable salts or compositions, are useful in treating diseases or conditions in which α7 nicotinic acetylcholine receptors (nAChRs) are known to be involved.