- Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage
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In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic acid (2) and 3-(3,4-dihydroxyphenyl)lactic acid (3). In this study, we investigated the structural requirements necessary for inhibition of snake venom activity through the use of compounds, which are structurally related to rosmarinic acid (1). By examining anti-hemorrhagic activity of cinnamic acid analogs against Protobothrops flavoviridis (Habu) venom, it was revealed that the presence of the E-enoic acid moiety (-CHCH-COOH) was critical. Furthermore, among the compound tested, it was concluded that rosmarinic acid (1) (IC50 0.15 μM) was the most potent inhibitor against the venom.
- Aung, Hnin Thanda,Furukawa, Tadashi,Nikai, Toshiaki,Niwa, Masatake,Takaya, Yoshiaki
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experimental part
p. 2392 - 2396
(2011/05/12)
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- Synthesis of diverse analogues of Oenostacin and their antibacterial activities
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Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC50 ranging from 0.49 to 0.67 μM as compared to Oenostacin (EC50 = 0.12 μM).
- Srivastava, Vandana,Darokar, Mahendra P.,Fatima, Atiya,Kumar,Chowdhury, Chinmay,Saxena, Hari Om,Dwivedi, Gaurav R.,Shrivastava, Kunal,Gupta, Vivek,Chattopadhyay,Luqman, Suaib,Gupta,Negi, Arvind S.,Khanuja, Suman P.S.
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p. 518 - 525
(2008/03/12)
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