13059-60-4

Basic information

• Product Name: GLYCYLGLYCINE HYDROCHLORIDE
• Synonyms: GLYCYLGLYCINE HYDROCHLORIDE;n-glycyl-glycinmonohydrochloride;N-glycylglycine monohydrochloride;glycyl-glycineHCl;Glycylglycine Hydrochloride Monohydrate;Einecs 235-951-2;Glycine, glycyl-, hydrochloride;Glycine, glycyl-, hydrochloride (1:1)
• CAS NO: 13059-60-4
• Molecular Formula: C₄H₈N₂O₃*ClH
• Molecular Weight: 168.58
• EINECS: 235-951-2
• Product Categories: Biochemistry;Oligopeptides;Peptide Synthesis;buffer
• Mol File: 13059-60-4.mol

Chemical Properties

• Boiling Point: 453.2 °C at 760 mmHg
• Flash Point: 227.9 °C
• Appearance: /
• Vapor Pressure: 1.78E-09mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: GLYCYLGLYCINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GLYCYLGLYCINE HYDROCHLORIDE(13059-60-4)
• EPA Substance Registry System: GLYCYLGLYCINE HYDROCHLORIDE(13059-60-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13059-60-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
GLYCYLGLYCINE HYDROCHLORIDE is used as an active pharmaceutical ingredient for its role in enhancing NMDA receptor mediated synaptic potentials, which can be beneficial in the treatment of certain neurological disorders.
Used in Adjuvant Therapy for Schizophrenia:
GLYCYLGLYCINE HYDROCHLORIDE is used as an adjuvant therapy for the treatment of schizophrenia, where it helps in managing the symptoms and improving the overall quality of life for patients.
Used in Research and Development:
GLYCYLGLYCINE HYDROCHLORIDE is also used in research and development for studying the functions and interactions of Glycine in various biological systems, contributing to a better understanding of its role in human health and disease.

Purification Methods

Crystallise the salt twice from 95% EtOH. Single crystals are formed by slow evaporation of an aqueous solution. [Parthasarathy Acta Cryst (B) 25 509 1969, Mellon & Hoover J Am Chem Soc 73 3879 1951, Garfinkel & Edsall J Am Chem Soc 80 3818 1958, Beilstein 4 IV 2469.]

InChI:InChI=1/C4H8N2O3.ClH/c5-1-3(7)6-2-4(8)9;/h1-2,5H2,(H,6,7)(H,8,9);1H

Upstream product

• 77930-08-6 C₁₉H₂₁F₂N₂O₅P 

Downstream Products

• 31384-90-4 hippuroyl-Gly-Gly 
• 76264-21-6 N-benzoyl-alanyl-glycyl-glycine 
• 62470-70-6 N-benzoyl-tetraglycyl-glycine 
• 15474-96-1 chloroacetyldiglycine 
• 94230-81-6 N-[N-(DL-2-bromo-4-methyl-valeryl)-glycyl]-glycine 
• 75509-30-7 N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine 
• 77374-52-8 Z-Cys(BzlOMe)-Gly₂-OH 
• 28140-52-5 o-nitrobenzenesulfenyl-glycyl-glycine 
• 60662-64-8 N-[N-(DL-2-bromo-propionyl)-glycyl]-glycine 
• 356570-67-7 N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester 
• 1310053-86-1 N-(p-bromobenzoyl)-L-alanylglycylglycine methyl ester 

Relevant articles and documents

ETUDE D'UN SCHEMA DE SYNTHESE PEPTIDIQUE INTRAMOLECULAIRE A L'AIDE DE DERIVES DU PHOSPHORE TETRAEDRIQUE

A new scheme of repetitive and controlled peptide synthesis offers two advantages compared to the usual methods of synthesis: two steps only are used for the prolongation of a peptide chain with an amino-acid residue and the risk of racemisation is minimized.The two postulated steps are verified particularly by the rearrangement, in an alkaline alcoholic medium, of phosphordiamides 1 incorporating one amino-acid residue, leading to the formation of the peptide derivatives 6 and 8.The severe limitations of this method are discussed.