- Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases
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A series of new Smac mimetics have been designed, synthesized, and evaluated. The most potent compound 10 binds to XIAP, cIAP-1, and cIAP-2 BIR3 proteins with Ki of 3.9, 0.37, and 0.25 nM, respectively. Compound 10 antagonizes XIAP in a cell-free function
- Sun, Wei,Nikolovska-Coleska, Zaneta,Qin, Dongguang,Sun, Haiying,Yang, Chao-Yie,Bai, Longchuang,Qiu, Su,Wang, You,Ma, Dawei,Wang, Shaomeng
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supporting information; experimental part
p. 593 - 596
(2009/12/25)
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- Synthesis and biological activity of (S)-2-amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A) derivatives
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(S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the structure
- Tamura,Matsushita,Iwama,Harada,Kishimoto,Itoh
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p. 1199 - 1212
(2007/10/02)
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