Novel tele nucleophilic aromatic substitutions in α-(benzotriazol-1-yl)alkyl aryl ketones
Reactions of α-(benzoltriazol-1-yl)alkyl aryl ketones 2 with alkyllithiums or Grignard reagents afforded para-alkylated products 5 via novel tele nucleophilic, aromatic substitutions.
Katritzky, Alan R.,Wu, Hong,Xie, Linghong
p. 903 - 906
(2007/10/03)
Tris(benzotriazol-1-yl)methane: A -CO2H Synthon for the Preparation of Carboxylic Acids
Lithiation of tris(benzotriazol-1-yl)methane 16 gives the tris(benzotriazolyl)methyl carbanion 17 which affords substitution products 18 with many electrophiles.Acidic hydrolysis of 18 affords the corresponding carboxylic acids 19 in good yield.The syntheses of several α-functionalized carboxylic acids are described.
Katritzky, Alan R.,Yang, Zhijun,Lam, Jamshed N.
p. 666 - 669
(2007/10/02)
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