Enantioselective synthesis of anti- and syn-β-hydroxy-α-phenyl carboxylates via boron-mediated asymmetric aldol reaction
A reagent-controlled, diastereo- and enantioselective synthesis of anti- and syn-β-hydroxy-α-phenyl carboxylates has been achieved by the proper choice of solvent, temperature, alkoxy group, and amine for the diisopinocampheylboron-mediated asymmetric enolization-aldolization of phenylacetates. The pure diastereomers can be readily separated by column chromatography.
Ramachandran, P. Veeraraghavan,Chanda, Prem B.
supporting information
p. 3152 - 3154
(2013/06/05)
REACTIONS OF TITANIUM DERIVATIVES OF CERTAIN CH ACIDS WITH CARBONYL COMPOUNDS. II. ALDOL CONDENSATIONS WITH TITANIUM DERIVATIVES OF BENZYL CYANIDE, ISOPROPYL PHENYLACETATE, AND PHENYL BENZYL AND ETHYL BENZYL KETONES
The titanium derivatives of benzyl cyanide, isopropyl phenylacetate, and phenyl benzyl and ethyl benzyl ketones, unlike the corresponding alkali-metal salts, react with aldehydes and ketones in THF at -78 to 20 deg C to form high yields of the products fr
Kasatkin, A. N.,Biktimirov, R. Kh.,Tolstikov, G. A.,Nikonenko, A. G.
p. 1037 - 1045
(2007/10/02)
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