Ruthenium-catalyzed cyclocarbonylation of aliphatic amides through the regioselective activation of unactivated C(sp3)-H bonds
The regioselective carbonylation of unactivated C(sp3)-H bonds of aliphatic amides, using 2-pyridinylmethylamine as a directing group in conjunction with Ru3(CO)12 as a catalyst is described. The presence of a 2-pyridinylm
Highly regioselective carbonylation of unactivated C(sp3)-H bonds by ruthenium carbonyl
The regioselective carbonylation of unactivated C(sp3)-H bonds of aliphatic amides was achieved using Ru3(CO)12 as a catalyst. The presence of a 2-pyridinylmethylamine moiety in the amide is crucial for a successful reaction. The reaction shows a preference for C-H bonds of methyl groups as opposed to methylene C-H bonds and tolerates a variety of functional groups. The stoichiometric reaction of an amide with Ru 3(CO)12 gave a dinuclear ruthenium complex in which the 2-pyridinylmethylamino moiety was coordinated to the ruthenium center in an N,N manner.