Direct Pd(II)-Catalyzed Site-Selective C5-Arylation of 2-Pyridone Using Aryl Iodides
A straightforward Pd(II)-catalyzed general strategy was developed for the C5-selective arylation of the 2-pyridone core with easily available aryl iodides. The transformation was highly regioselective and accomplished with a wide scope and functional group tolerance. Silver nitrate played a crucial role in this direct site-selective arylation. The method was extended to synthesize biologically active molecules.
GENERATION OF SPECIFICALLY SUBSTITUTED PYRIDINES AND PYRIDONES FROM 2(1H) PYRAZINONES AND ACETYLENES: A FMO DESCRIPTION
The title compounds were obtained from reaction of variously substituted 2(1H)pyrazinones with acetylenic derivatives.Experimental evidence points out to a two step mechanism: a Diels Alder cycloaddition followed by immediate decomposition of the adducts
Tutonda, M.,Vanderzande, D.,Hendrickx, M.,Hoornaert, G.
p. 5715 - 5732
(2007/10/02)
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