Highly enantioselective partial hydrogenation of simple pyrroles: A facile access to chiral 1-pyrrolines
A highly enantioselective Pd-catalyzed partial hydrogenation of simple 2,5-disubstituted pyrroles with a Bronsted acid as an activator has been successfully developed, providing chiral 2,5-disubstituted 1-pyrrolines with up to 92% ee.