131-53-3Relevant articles and documents
2. 2' - dihydroxy - 4 - methoxy benzophenone preparation method
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Paragraph 0028; 0029; 0032; 0033; 0036; 0037; 0040-0045, (2017/08/26)
A preparation method of 2,2'-dihydroxy-4-methoxybenzophenone comprises the following steps: synthesizing 2,2'4-trihydroxybenzophenone from salicylic acid and resorcinol, and carrying out a methylation reaction on 2,2'4-trihydroxybenzophenone and dimethyl sulfate to prepare 2,2'-dihydroxy-4-methoxybenzophenone. The method has the advantages of high purification efficiency, good separation effect of byproducts, high product purity reaching 99.5%, and realization of industrial production requirements of the above product.
Rh-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones
Rao, Maddali L. N.,Ramakrishna, Boddu S.
, p. 75505 - 75511 (2016/08/24)
An efficient rhodium-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones was developed from functionalized salicylaldehydes. This approach provides an easy access to various functionalized 2,2′-dihydroxybenzophenone and xanthone core s
A 2, 2 the [...] -dihydroxy-4-methoxy benzophenone synthetic method
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Paragraph 0028; 0029; 0031, (2017/01/12)
The invention provides a synthetic method of 2,2'-dyhydroxyl-4-methoxyl diphenyl ketone. The method comprises the following steps: (1) reacting m-benzene dimethylether with o-methoxybenzoyl chloride for 1-10 hours at the temperature of 0-80 DEG C under the irradiation of light having specific wavelength to obtain an intermediate product 2,2',4-triethoxy diphenyl ketone; (2) carrying out a selective demethylation reaction on the intermediate product 2,2',4-triethoxy diphenyl ketone obtained in the step (1) and a demethylating reagent for 5-16 hours at a reaction temperature of 40-120 DEG C and then performing water washing, liquid separation and recrystallization after the reaction ends to obtain 2,2'-dyhydroxyl-4-methoxyl diphenyl ketone (II). The method is low in reaction energy consumption, high in raw material recovery rate, simple in aftertreatment and small in environment pollution, so the method satisfies the development of environmental-friendly chemistry.
Cosmetic compositions
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, (2014/07/08)
Suggested is a cosmetic compositions comprising (a) a crosspolymer obtained from copolymerisation of at least two different polyols and at least one dicarboxylic acid and (b) at least one fragrance.
A composition for lightening skin and hair
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, (2014/10/28)
Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent.
Pd-catalyzed sp2 C-H hydroxylation with TFA/TFAA via weak coordinations
Rao, Yu
, p. 2472 - 2476 (2013/12/04)
An efficient sp2 C-H hydroxylation has been developed for the synthesis of a wide range of functionalized phenols with aryl ketones, benzoates, benzamides, acetanilides and sulfonamides through palladium(II) catalysis. A trifluoroacetic acid (TFA)/trifluoroacetic anhydride (TFAA) co-solvent system serves as the oxygen source and is the critical factor for weak coordination promoted C-H activation. Georg Thieme Verlag Stuttgart New York.
Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: A convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis
Shan, Gang,Han, Xuesong,Lin, Yun,Yu, Shanyou,Rao, Yu
supporting information, p. 2318 - 2322 (2013/04/10)
A unique Rh(ii) and Ru(ii) catalyzed C-H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified in further applications in heterocycle synthesis and direct modifications of drug Fenofibrate.
Synthesis of ortho-acylphenols through the palladium-catalyzed ketone-directed hydroxylation of arenes
Mo, Fanyang,Trzepkowski, Louis J.,Dong, Guangbin
supporting information, p. 13075 - 13079 (2013/02/25)
ortho-Acylphenols are an important structural motif found in a diversity of bioactive molecules ranging from natural products to drugs (Figure 1). Moreover, they also serve as versatile building blocks for the synthesis of various pharmaceuticals, such as warfarin, as well as agrichemicals, flavors, and fragrances. Classic approaches to the synthesis of o-acylphenols generally involve a two-step process: acylation of phenols followed by Fries rearrangement of the resulting phenyl esters (Scheme 1a). On the other hand, direct C-acylation of phenols has also been known under more forcing conditions. Although effective, these approaches are often complicated by the formation of undesired p-substituted products when bulky acyl groups need to be introduced, as well as the limited variety of ketones that can be generated.
Pd-catalyzed C-H oxygenation with TFA/TFAA: Expedient access to oxygen-containing heterocycles and late-stage drug modification
Shan, Gang,Yang, Xinglin,Ma, Linlin,Rao, Yu
supporting information, p. 13070 - 13074 (2013/02/26)
Functionalized phenols are valuable industrial chemicals related to pharmaceuticals, agrochemicals, and polymers. Therefore, the direct catalytic hydroxylation of arenes to produce phenols has attracted much attention. Although tremendous progress has been made in this field, there are still difficult substrates which remain unmet challenges for direct hydroxylation in terms of regio- and chemoselectivity, as well as the practicality of current methods (Scheme 1). For example, 2-hydroxy aromatic ketones are useful synthetic intermediates for the preparation of various oxygen-containing heterocycles such as benzofuranone, chromanone, benzoxazole, and dibenzooxazepine; they also serve as key building blocks for drugs such as celiprolol, acebutolol, and propafenone. Traditional strategies for accessing 2-hydroxy aromatic ketones have mainly involved the oxidation of benzylic alcohols, the hydrolysis of aromatic halides, Fries rearrangement of esters or the demethylation of methyl phenyl ether. These methods generally suffer from one limitation or another, such as tedious reaction procedures, harsh reaction conditions, low yields, or the formation of side products. Hence, direct transformation of readily available aromatic ketones into valuable 2-hydroxylated products by transition metal-catalyzed C-H functionalization is arguably a highly efficient and atom-economic method to access these compounds. Moreover, developing a more general strategy for the regio- and chemoselective C-H oxygenation of a variety of challenging arenes would be especially desirable for phenol synthesis (Scheme 1).
Method of purifying arylphenones
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, (2008/06/13)
Hydroxy and alkyloxy benzophenones, also known as arylphenones, are efficiently and economically purified by contacting them with inorganic phosphorous compounds in the presence of a non-polar solvent. Best results are obtained when the arylphenone is then treated with an activated carbon and/or activated clay.
