Palladium-catalyzed asymmetric alkylation via II-allyl intermediate: Acetamidomalonate ester as a nucleophile
Asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with sodium salt of acetamidomalonate ester has been carried out in the presence of a palladium catalyst containing (S)-BINAP to give a chiral α-allyl-α-acetamidomalonate ester derivative of high optical purity (94 ± 1% ee).
Yamaguchi,Shima,Yamagishi,Hida
p. 5049 - 5052
(2007/10/02)
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