Semisynthesis of triptolide analogues: Effect of γ-lactone and C-14 substituents on cytotoxic activities
Triptolide γ-lactone and C-14 analogues were prepared and evaluated cytotoxity against human lung adenocarcinoma epithelial A549 cells and human colon adenocarcinoma HT-29 cells. γ-Lactone substructure and C-14 substituents affected the biological activities significantly.