METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS
The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein. Also provided are methods and kits for treating cancer and solid tumors in a subject, as well as methods and kits for inducing cancer cell death and apoptosis of a cancer cell, all utilizing the NF-κB inhibitors described herein.
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Paragraph 0447; 0454
(2019/01/15)
SMALL MOLECULE NF-kB INHIBITORS
The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein.
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Paragraph 0137
(2017/07/14)
Syntheses of 5′-O-desmethylterphenyllin and related p-terphenyls and their inhibitory activity of TNF-α release from RBL-2H3 cells
The first total syntheses of 5′-O-desmethylterphenyllin and three related p-terphenyls have been achieved. The methodology features a Suzuki-Miyaura coupling reaction with a hindered aryl chloride as the key step. Two of the four synthesized 5′-O-desmethylterphenyllins exhibit moderate TNF-α release-inhibitory activity toward RBL-2H3 cells.
Photodegradable groups for tunable polymeric materials
Provided is a method that provides both spatial and temporal control of a polymer degradation process using mono- and multifunctional macromolecular monomers (“macromers”) that degrade via single- and multi-photon photolysis mechanisms over a broad range
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Page/Page column 17
(2013/02/28)
Photodegradable hydrogels to generate positive and negative features over multiple length scales
Here we present a photodegradable hydrogel as a biocompatible, nonfouling photoresist capable of presenting positive and negative features through single-photon and two-photon degradation. An ortho-nitrobenzylether (o-NBE) moiety is used as a polymerizabl
Wong, Darice Y.,Griffin, Donald R.,Reed, Jason,Kasko, Andrea M.
experimental part
p. 2824 - 2831
(2011/10/09)
Total synthesis of topopyrones B and D
(Chemical Equation Presented) We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.
Tan, Jason Samuel,Ciufolini, Marco A.
p. 4771 - 4774
(2007/10/03)
Atropselective macrocyclization of diaryl ether ring systems: Application to the synthesis of vancomycin model systems
Vancomycin is the last line of defense available in the clinic for treating multidrug-resistant bacterial infections. Vancomycin contains two 16-membered diaryl ether macrocycles, each of which contains a stereogenic axis across the diaryl ether linkage.
Nicolaou,Boddy, Christopher N. C.
p. 10451 - 10455
(2007/10/03)
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