Total synthesis of the ethyl ester of the major urinary metabolite of prostaglandin E2
The preparation of the ethyl ester of the major urinary metabolite of prostaglandin E2 3 is described. The key step is the kinetic opening of the TBS-protected bicyclic ketone 7 with thiophenol.
Preparation of the major urinary metabolite of (-)-prostaglandin E2
The best way to measure whole body production of the locally acting hormone prostaglandin E2 (PGE2) is to assess the accumulation of the major urinary metabolite, PGE2UM. A practical preparation of this delicate