Reaction of an electrogenerated 'iminium cation pool' with organometallic reagents. Direct oxidative α-alkylation and -arylation of amine derivatives
We have developed an efficient direct oxidative α-alkylation and -arylation of carbamates based on the 'cation pool' method. Grignard reagents, organozinc compounds, and organoaluminum compounds are effective as carbon nucleophiles toward iminium cation pools generated by low temperature electrolysis of carbamates.
Suga, Seiji,Okajima, Masayuki,Yoshida, Jun-ichi
p. 2173 - 2176
(2007/10/03)
Selective Cleavage of N-Acylated N,O-Acetals with RCu-BF3. Synthesis of Cyclic α-Alkylated Amides and Carbamates
Cyclic α-methoxylated amides and carbamates are selectively cleaved with RCu-BF3 to give α-alkylated amides and carbamates.Substrates containing a chiral auxiliary (1d and 3d) gave low ( 10percent) degrees of asymmetric induction.
Ludwig, Catarina,Wistrand, Lars-G.
p. 707 - 710
(2007/10/02)
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