Rigid analogues of antimitotic indolobenzazepinones: New insights into tubulin binding via molecular modeling
Two rigid analogues of 5-ethylindolobenzazepinone 4, a potent cytotoxic agent and inhibitor of tubulin polymerization, were prepared. The first was the indane derivative 5, in which the ethyl group is attached to the benzo moiety. The second was the pyrro
Pons, Valerie,Beaumont, Stephane,Tran Huu Dau, Marie Elise,Iorga, Bogdan I.,Dodd, Robert H.
p. 565 - 570
(2011/10/02)
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