13123-35-8

Basic information

• Product Name: H-TRP-LEU-OH
• Synonyms: H-TRP-LEU-OH;L-TRP-LEU;L-TRYPTOPHYL-L-LEUCINE;TRP-LEU;L-Leucine, L-tryptophyl-;Nsc286600;(S)-2-((S)-2-AMino-3-(1H-indol-3-yl)propanaMido)-4-Methylpentanoic acid
• CAS NO: 13123-35-8
• Molecular Formula: C17H23N3O3
• Molecular Weight: 317.38
• Mol File: 13123-35-8.mol

Chemical Properties

• Boiling Point: 624.2°Cat760mmHg
• Flash Point: 331.3°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 1.92E-16mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: -15°C
• CAS DataBase Reference: H-TRP-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-TRP-LEU-OH(13123-35-8)
• EPA Substance Registry System: H-TRP-LEU-OH(13123-35-8)

Safety Data

• Hazardous Substances Data: 13123-35-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
H-TRP-LEU-OH is utilized as a key component in the development of new pharmaceuticals, leveraging its role in protein synthesis and its potential to influence neurotransmitter levels for various therapeutic applications.
Used in Biochemical Research:
In biochemical research, H-TRP-LEU-OH is employed as a substrate or a model compound to study peptide and protein interactions, as well as to investigate the functions of the constituent amino acids, tryptophan and leucine.
Used in Biomedical Research:
H-TRP-LEU-OH is used as a research tool in biomedical studies to explore its potential in diagnostics, therapeutics, and understanding the mechanisms of diseases related to protein synthesis and neurotransmission.
Used in Sports Supplements Industry:
H-TRP-LEU-OH is used as an ingredient in sports supplements for its muscle growth and recovery promoting properties, capitalizing on the essential amino acid leucine's role in these processes.
Used in Peptide and Protein Synthesis:
H-TRP-LEU-OH is used as a building block in the synthesis of custom peptides and proteins for various applications, including but not limited to, pharmaceuticals, research reagents, and industrial enzymes.

InChI:InChI=1/C17H23N3O3/c1-10(2)7-15(17(22)23)20-16(21)13(18)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1

Upstream product

• 120151-95-3 1,7-dioxo-2,5,6-trimethyl-1H,7H-pyrazolo<1,2-a>pyrazol-3-yl-methylthiomethylcarbonyl-L-phenylalanyl-L-tryptophyl-L-leucine 
• 120151-93-1 1,7-dioxo-2,5,6-trimethyl-1H,7H-pyrazolo<1,2-a>pyrazol-3-yl-methylthiomethylcarbonyl-glycyl-L-tryptophyl-L-leucine 

Downstream Products

• 120151-95-3 1,7-dioxo-2,5,6-trimethyl-1H,7H-pyrazolo<1,2-a>pyrazol-3-yl-methylthiomethylcarbonyl-L-phenylalanyl-L-tryptophyl-L-leucine 

Relevant articles and documents

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.