1312413-74-3

Basic information

• Product Name: 6-Bromo-2-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine
• Synonyms: 6-Bromo-2-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine
• CAS NO: 1312413-74-3
• Molecular Formula: C11H12BrN3O
• Molecular Weight: 282.13648
• Mol File: 1312413-74-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Bromo-2-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine(1312413-74-3)
• EPA Substance Registry System: 6-Bromo-2-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine(1312413-74-3)

Safety Data

• Hazardous Substances Data: 1312413-74-3(Hazardous Substances Data)

Relevant articles and documents

ETHYNYL DERIVATIVES

The present invention relates to ethynyl derivatives of formula (I) wherein X is N or C-R1; Y is N or C-R2; Z is CH or N; R4 is a 6-membered aromatic substituent containing 0, 1 or 2 nitrogen atoms, optionally substituted by 1 to 3 groups, selected from halogen, lower alkyl, lower alkoxy or NRR'; R1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, lower hydroxyalkyl, lower cycloalkyl or is heterocycloalkyl optionally substituted with hydroxy or alkoxy; R2 is hydrogen, CN, lower alkyl or heterocycloalkyl; R and R' are independently from each other hydrogen or lower alkyl; or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula (I) are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.

ETHYNYL COMPOUNDS USEFUL FOR TREATMENT OF CNS DISORDERS

The present invention relates to ethynyl compounds of formula wherein X, Y, Z, and R4 are as defined herein or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.