The present invention relates to polyamine derivatives of the formula RHN-(CH2)m-NH-(CH2)n-NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C2-C6 alkyl or -(CH2)p-Ar wherein Ar is phenyl or naphthyl and p is an integer from 0
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(2008/06/13)
Antimalarial Polyamine Analogues
A series of novel tetraamines of the general formula RNH(CH2)xNH(CH2)yNH(CH2)xNHR was synthesized and examined for activity against growth of Plasmodium falciparum in vitro.Within the series, dibenzyl analogues (R = benzyl) were found to be the most effec
Edwards, M. L.,Stemeric, D. M.,Bitonti, A. J.,Dumont, J. A.,McCann, P. P.,et al.
p. 569 - 574
(2007/10/02)
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