Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues
Combretastatin A-4 (CA-4) is a potent tubulin depolymerizing agent able to inhibit tumor growth and with antivascular effects. Although it is in clinical trials, the search for novel analogues that may display better/different features is still ongoing. I
Theeramunkong, Sewan,Caldarelli, Antonio,Massarotti, Alberto,Aprile, Silvio,Caprioglio, Diego,Zaninetti, Roberta,Teruggi, Alessia,Pirali, Tracey,Grosa, Giorgio,Tron, Gian Cesare,Genazzani, Armando A.
supporting information; experimental part
p. 4977 - 4986
(2011/10/01)
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