Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors
Methylation of histones by lysine methyltransferases (KMTases) plays important roles in regulating chromatin function. It is also now clear that improper KMTases activity is linked to human diseases, such as cancer. We report an approach that employs drug
Kashyap, Sudhir,Sandler, Joel,Peters, Ulf,Martinez, Eduardo J.,Kapoor, Tarun M.
p. 2253 - 2260
(2014/04/17)
LYSINE AND ARGININE METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER
Compounds having lysine or arginine methyltransferase inhibitory activity and their use in the treatment of diseases and conditions associated with inappropriate methyltransferase activity are disclosed. The compounds are of the general formula (I).
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(2011/07/30)
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