Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B reeeptors
We previously reported novel Boc-CCK-4 (Boc-Trp-Met-Asp-Phe-NH2) derivatives possessing the general structure Boc-Trp-Lys[Nε-CO-NH-(R-Ph)]- Asp-Phe-NH2 (Shiosaki et al. J. Med. Chem. 1991, 34, 2837-2842). In contrast to Boc-CCK-4, wh
Shiosaki,Chun Wel Lin,Kopecka,Bianchi,Miller,Stashko,Witte
p. 1169 - 1172
(2007/10/03)
Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists
Novel Boc-CCK-4 derivatives were communicated recently as having high potency and selectivity for the CCK-A receptor (Shiosaki et al. J. Med. Chem. 1990, 33, 2950-2952). While Boc-CCK-4 binds selectively to the CCK-B receptor, replacement of the methionin
Get Best Price for131449-92-8(S)-3-{(S)-6-[3-(3-Acetyl-phenyl)-ureido]-2-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid