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5-(broMoMethyl)quinoxaline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

131454-80-3

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131454-80-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 131454-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,4,5 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 131454-80:
(8*1)+(7*3)+(6*1)+(5*4)+(4*5)+(3*4)+(2*8)+(1*0)=103
103 % 10 = 3
So 131454-80-3 is a valid CAS Registry Number.

131454-80-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(Bromomethyl)quinoxaline

1.2 Other means of identification

Product number -
Other names 5-bromomethyl-quinoxaline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:131454-80-3 SDS

131454-80-3Downstream Products

131454-80-3Relevant articles and documents

Building blocks for cyclotriveratrylene-based coordination networks

Hardie, Michaele J.,Mills, Rachael M.,Sumby, Christopher J.

, p. 2958 - 2964 (2004)

The incorporation of three-fold symmetric organic host molecules into coordination polymers should allow for the construction of new and interesting network structures, capable of multiple inclusion behaviour. A range of new multi-dentate bridging ligands/molecular hosts have been prepared by appending nitrogen-containing heterocycles to either cyclotricatechylene, or cyclotriguaiacylene cores. These compounds were obtained in a single-step reaction from readily available precursors, with moderate to good yields, and characterised by a combination of NMR spectroscopy, mass spectrometry and elemental analysis. Two of the new compounds were characterised by X-ray crystallography, revealing different modes of self inclusion behaviour, which indicate the potential importance of π-donor stabilisation by CTV derivatives in host-guest chemistry.

PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS

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Page/Page column 68, (2017/03/21)

The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide???Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket

Giroud, Maude,Ivkovic, Jakov,Martignoni, Mara,Fleuti, Marianne,Trapp, Nils,Haap, Wolfgang,Kuglstatter, Andreas,Benz, J?rg,Kuhn, Bernd,Schirmeister, Tanja,Diederich, Fran?ois

supporting information, p. 257 - 270 (2017/02/15)

We report an extensive “heteroarene scan” of triazine nitrile ligands of the cysteine protease human cathepsin L (hCatL) to investigate π-stacking on the peptide amide bond Gly67–Gly68 at the entrance of the S3 pocket. This heteroarene???peptide bond stacking was supported by a co-crystal structure of an imidazopyridine ligand with hCatL. Inhibitory constants (Ki) are strongly influenced by the diverse nature of the heterocycles and specific interactions with the local environment of the S3 pocket. Binding affinities vary by three orders of magnitude. All heteroaromatic ligands feature enhanced binding by comparison with hydrocarbon analogues. Predicted energetic contributions from the orientation of the local dipole moments of heteroarene and peptide bond could not be confirmed. Binding of benzothienyl (Ki=4 nm) and benzothiazolyl (Ki=17 nm) ligands was enhanced by intermolecular C?S???O=C interactions (chalcogen bonding) with the backbone C=O of Asn66 in the S3 pocket. The ligands were also tested for the related enzyme rhodesain.

Novel multi-functional nitrones for treatment of ischemic stroke

Sun, Yewei,Zhang, Gaoxiao,Zhang, Zaijun,Yu, Pei,Zhong, Haijing,Du, Jing,Wang, Yuqiang

scheme or table, p. 3939 - 3945 (2012/08/13)

Ischemic stroke resulting from obstruction of blood vessels is an enormous public health problem with urgent need for effective therapy. The co-administration of thrombolytic/antiplatelet agent and neuroprotective agent improves therapeutic efficacy and agent possessing both thrombolytic/ antiplatelet and antiradical activities provides a promising strategy for the treatment of ischemic stroke. We have previously reported a novel compound, namely TBN, possessing both antiplatelet and antiradical activities, showed significant neuroprotective effect in a rat stroke model. We herein report synthesis of a series of new pyrazine derivatives, and evaluation of their biological activities. Their mechanisms of action were also investigated. Among these new derivatives, compound 21, armed with two nitrone moieties, showed the greatest neuroprotective effects in vitro and in vivo. Compound 21 significantly inhibited ADP-induced platelet aggregation. In a cell free antiradical assay, compound 21 was the most effective agent in scavenging the three most damaging radicals, namely .OH, O2.- and ONOO -.

PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF

-

Page/Page column 14, (2012/02/01)

Pyrazine derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein the designation of R1, R2, R3 and R4 are provided herein. Syntheses for preparation of such compounds are disclosed. Methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments are disclosed. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS

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Page/Page column 102, (2011/02/24)

The present invention relates to benzoxazinone derivatives, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in treating disorders mediated by GlyT1, including neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder.

(1H-azol-1-ylmethyl)substituted quinoxaline derivatives

-

, (2008/06/13)

(1H-azol-1-ylmethyl)substituted quinoxaline derivatives, compositions containing the same, and methods of treating mammals suffering from disorders which are characterized by an increased proliferation and/or abnormal differentiation of epithelial tissues

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