A two-step synthesis of 2-exo-substituted 2-endo-aminonorbornenes from 2-acetamidonorbornene-2-carboxylic acids
2-exo-Substituted 2-endo-acetamidonorbornenes (3) were synthesized in a two-step procedure from 2-acetamidonorbornene-2-carboxylic acids (1, 1') with exceedingly high exo-selectivities based on a new approach involving anodic decarboxylation followed by o
A SYNTHESIS OF 2-EXO-SUBSTITUTED 2-ENDO-AMINONORBORNENES: ORGANOALUMINUM-PROMOTED NUCLEOPHILIC SUBSTITUTION ON 2-ENDO-ACETAMIDO-2-EXO-METHOXYNORBORNENE
A variety of 2-exo-substituted 2-endo-acetamidonorbornenes (2a-g) were synthesized in exceedingly high exo selectivities by organoaluminum-promoted nucleophilic substitution on 2-endo-acetamido-2-exo-methoxynorbornene.