13147-14-3

Basic information

• Product Name: 2.3-Dichlorophenyl Hydrazine
• Synonyms: 2.3-Dichlorophenyl Hydrazine
• CAS NO: 13147-14-3
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03124
• Mol File: 13147-14-3.mol

Chemical Properties

• Melting Point: 113.5-115.4 °C
• Boiling Point: 272.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.475±0.06 g/cm3(Predicted)
• PKA: 4.32±0.10(Predicted)
• CAS DataBase Reference: 2.3-Dichlorophenyl Hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2.3-Dichlorophenyl Hydrazine(13147-14-3)
• EPA Substance Registry System: 2.3-Dichlorophenyl Hydrazine(13147-14-3)

Safety Data

• Hazardous Substances Data: 13147-14-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dichlorophenyl Hydrazine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-Dichlorophenyl Hydrazine serves as an essential intermediate for the production of various agrochemicals. Its role in the synthesis of these compounds contributes to the development of effective pesticides and other agricultural products designed to protect crops and enhance agricultural productivity.

Upstream product

• 608-27-5 2,3-dichloroaniline 
• 73260-77-2 2,3-Dichloro-benzenediazonium; chloride 

Downstream Products

• 120640-04-2 maleic acid mono-[N'-(2,3-dichloro-phenyl)-hydrazide] 
• 96423-53-9 N-(2,3-Dichloro-phenyl)-N'-(4,5-dihydro-thiazol-2-yl)-hydrazine; hydrobromide 
• 96423-61-9 N-(2,3-Dichloro-phenyl)-N'-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-hydrazine; hydrochloride 
• 77606-83-8 2-(2,3-Dichloro-phenyl)-1,4-dihydro-2H-thiochromeno[4,3-c]pyrazol-3-one 
• 76989-44-1 5-Amino-4-cyan-1-(2,3-dichlorphenyl)-3-methylpyrazol 
• 957055-22-0 C₁₄H₉Cl₂N 
• 957055-23-1 C₁₅H₁₁Cl₂N 
• 957055-24-2 C₁₉H₁₅NO 
• 76982-36-0 4-Amino-1-(2,3-dichlorphenyl)-3-methyl-1H-pyrazolo<3,4-d>pyrimidin 
• 1000271-20-4 N-(2,3-dichlorophenyl)-N-(3-methylbenzyl)hydrazine hydrochloride 
• 1245573-97-0 C₁₆H₁₉Cl₂N₃O₃ 
• 1245573-96-9 C₁₇H₂₁Cl₂N₃O₃ 

Relevant articles and documents

Anthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship

A series of novel anthranilic diamides derivatives (7a–s) containing halogen, trifluoromethyl group and cyano group were designed, synthesized, and characterized by melting point, 1H NMR, 13C NMR and elemental analyses. The bioactivity revealed that most of them showed moderate to excellent activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). Above all, the larvicidal activity of 7o against oriental armyworm was 100% and 40% at 0.25 and 0.1 mg L?1, comparable to that of the standard chlorantraniliprole (100%, 0.25 mg L?1 and 20%, 0.1 mg L?1). What is more, 7o against diamondback moth displayed 90% insecticidal activity at 0.01 mg L?1, superior to chlorantraniliprole (45%, 0.01 mg L?1). The experiments 7o on the American cockroach (Periplaneta Americana) heart beating rates (Dorsal vessel) and contractile force were compared with chlorantraniliprole. In addition, 7o could affect the calcium homeostasis in the central neurons of the third larvae of oriental armyworm, which revealed that the ryanodine receptor is the potential target of 7o. The density functional theory (DFT) calculation results revealed the amide bridge, the benzene ring of anthraniloyl moiety and pyrazole ring might play an important role in the insecticidal activity through hydrophobic interactions and π-π conjugations.

SUBSTITUTED PYRAZOLYL-BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH AN O-CONTAINING GROUP AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives of formula (Q) as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Indole-derived arynes and their diels - Alder reactivity with furans

Arynes derived from any position of the ubiquitous indole nucleus are unknown. We have now provided the first evidence for the formation and trapping of the 4,5-, 5,6-, and 6,7-indolynes. A series of o-dihalo indoles (CI, Br, F) were synthesized and reacted under metal-halogen exchange conditions to give Diels-Alder cycloadducts in high yield with furan. The use of an excess of fert-butyllithium resulted in the rearrangement of the initially formed cycloadduct; however, employing only a slight excess of n-butyllithium cleanly gave cycloadducts with furan.

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.