- PROCESSES FOR THE PRODUCTION OF 14 - OXYGENATED MORPHINAN - 6 - ONES
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A process for the production of a 14-oxygenated morphinan-6-one of formula (I) wherein R1 is alkyl, alkenyl, alkynyl, cycloalkylalkyl, aralkyl, R3 is hydrogen, and R4 is hydrogen, wherein oripavine, 14-hydroxymorphinone or oxymorphone is used as starting material.
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- Process for the synthesis of 14-oxygenated morphinan-6-ones
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A process for the production of 14-oxygenated morphinan-6-ones wherein a methylether group in position 3 of the phenyl ring which has to be cleaved to obtain the hydroxy group, and wherein the protection of the hydroxy group in position 3 of the phenyl ring in the presence of a ketal group is avoided.
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- 160. Synthesis and Biological Evaluation of 14-Alkoxymorphinans - Part 7 - 14,14'-Dimethoxy Analogues of Norbinaltorphimine: Synthesis and Determination of Their χ Opioid Antagonist Selectivity
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The bimorphinans 6 and 7 have been prepared from 14-O-methylnaloxone (2) and 14-O-methylnaltrexone (3), respectively.The known compounds 2 and 3 were synthesized by a different route than the route described.Bimorphinan 7 possessed a similar ξ receptor af
- Schmidhammer, Helmut,Ganglbauer, Ernst,Mitterdorfer, Joerg,Rollinger, Judith M.,Smith, Colin F. C.
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p. 1779 - 1783
(2007/10/02)
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