131654-77-8

Basic information

• Product Name: 1H-Pyrazole-1-propanol,5-amino-(9CI)
• Synonyms: 1H-Pyrazole-1-propanol,5-amino-(9CI)
• CAS NO: 131654-77-8
• Molecular Formula: C6H11N3O
• Molecular Weight: 141.17104
• Product Categories: VARIOUSAMINE
• Mol File: 131654-77-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazole-1-propanol,5-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-1-propanol,5-amino-(9CI)(131654-77-8)
• EPA Substance Registry System: 1H-Pyrazole-1-propanol,5-amino-(9CI)(131654-77-8)

Safety Data

• Hazardous Substances Data: 131654-77-8(Hazardous Substances Data)

Usage

Derivative of pyrazole

Yes

Contains a propanol group

Yes

Contains an amino group

Yes

Potential applications

Pharmaceutical industry (development of drugs targeting various biological pathways)

Use as a building block for synthesis

Potential

Suggests biological activity

Yes

Further research and study

Recommended for medicinal chemistry and drug development.

Upstream product

• 131654-76-7 5-amino-1-(2-methoxycarbonylethyl)pyrazole 

Relevant articles and documents

Studies on 3'-quaternary ammonium cephalosporins-IV. Synthesis and antibacterial activity of 3'-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037

The synthesis and in vitro antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido] cephalosporins bearing various 2-alkyl-3-aminopyrazolium groups at the 3-position are described. Antibacterial activity against MRSA was affected by the nature of the substituent at the 2-position on the 3'-aminopyrazolium groups. Among the cephalosporins prepared in this study, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[3-amino-2-(2 -hydroxyethyl)-pyrazolio]methyl-3-cephem-4-carboxylate sulfate (23e, FK037) showed extremely potent broad-spectrum activity against both Gram-positive bacteria including MRSA, and Gram-negative bacteria including Pseudomonas aeruginosa. In particular, the in vivo activity against MRSA of FK037 was the highest of all the β-lactam antibiotics tested.

Cephem compound

The invention relates to antimicrobial compounds of the formula: STR1 wherein R1 is amino or a protected amino, R2 is ethyl, propyl or lower alkenyl, R3 is COO θ, carboxy or a protected carboxy, R4 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R5 is amino or a protected amino, Xθ is an anion, and n is 0 or 1, or, R1, R3, R5, Xθ and n are each as defined above, R2 is lower alkyl, and R4 is 3-hydroxypropyl, with proviso that (i) when R3 is COOθ, then n is 0, and (ii) when R3 is carboxy or a protected carboxy, then n is 1, or a pharmaceutically acceptable salt thereof.