- Direction of the Dipole Moment in the Ester Group
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The directions of the dipole moments in esters RCOOR' in which R and R' are alkyl or aryl groups have been deduced by analysis of experimental values of dipole moments of six compounds containing two polar groups, one or both of which are esters.New determinations of molecular dipole moments are reported for dimethyl trans-1,4-cyclohexanedicarboxylate and for trans-1,4-cyclohexanediol diacetate.The moment of the ester group is directed (in the positive sense) at an angle τE=123 +/- 3 deg from the R-CO axis in both aromatic and aliphatic esters, formates excepted.
- Salz, E.,Hummel, J. P.,Flory, P. J.,Plavslc, M.
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Read Online
- An improved acid chloride preparation via phase transfer catalysis
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Phase transfer catalysis has been found to be effective for the rapid conversion of carboxylic acids in high yield to the corresponding acid chlorides. The procedure is well suited for acids that exhibit low solubilities in normal organic solvents.
- Burdett
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Read Online
- METHOD FOR PRODUCING ACID HALIDE SOLUTION, MIXED SOLUTION, AND METHOD FOR PRODUCING MONOESTER COMPOUND
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The present disclosure provides a method for producing an acid halide solution that is useful as a production intermediate or the like that allows industrially advantageous production of a polymerizable liquid crystal compound. The method for producing an
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Paragraph 0137-0144; 0155-0156; 0159-0161; 0170
(2019/01/04)
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- Method for preparing 1, 4-diphenyl cyclohexanedicarboxylate
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The invention belongs to the field of chemical synthesis and specifically relates to a method for preparing 1, 4-diphenyl cyclohexanedicarboxylate. The method comprises the following steps: performinga reaction in a solvent under the action of a catalyst
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Paragraph 0012; 0039-0050; 0051; 0063; 0075; 0087-0093
(2018/03/26)
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- As a polymer skeleton [...][...] compound and method of manufacturing same
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PROBLEM TO BE SOLVED: To provide a dinaphthothiophene compound useful as a refractive index improver for a plastic optical material, and a polymer comprising a dinaphthothiophene skeleton.SOLUTION: The dinaphthothiophene compound of the present invention
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Paragraph 0064
(2018/05/15)
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- POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
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PROBLEM TO BE SOLVED: To provide a polymerizable compound which has high storage stability and can form a film-like polymer while being difficult to cause alignment defects, where the film-like polymer is less likely to be separated from a substrate even when irradiated with ultraviolet for a long time. SOLUTION: The invention provides a compound represented by general formula (I), and a polymer thereof. A composition comprising the compound is useful as a polymerizable liquid crystal composition. (For example, the compound is bis[4-(acryloyloxyethoxy-ethoxy-ethoxy)phenyl]1,4-cyclohexanedicarboxylate.) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
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Paragraph 0169-0170
(2018/04/21)
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- acyl triazole derivative and its manufacturing method
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PROBLEM TO BE SOLVED: To provide a novel acyl triazole derivative that can be synthesized at low cost by a convenient method, has a comparable reactivity to an acid chloride with an amine compound and an alcohol compound, and can be safely handled, and a method of manufacturing the same; the acyl triazole derivative that is useful as a reactant applied to polymerization reaction to be continued; and a monomer comprising the same.SOLUTION: An acyl triazole derivative is shown by formula (1). In the formula, A denotes a substituted arylene group, a 1,3-phenylene group, a bisarylene group, a polycyclic arylene group, an alkylene group or an aralkylene group.
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Paragraph 0054
(2017/04/03)
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- POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, AND FILM
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PROBLEM TO BE SOLVED: To provide a novel polymerizable compound available as a low birefringent liquid crystal, and a film such as a low birefringent phase difference film and a reflective film with high selectivity on a reflection wavelength range. SOLUT
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Paragraph 0096; 0097
(2017/11/01)
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- POLYMERIZABLE COMPOUND, POLYMER, POLYMERIZABLE COMPOSITION, FILM, AND HALF MIRROR FOR DISPLAYING PROJECTION IMAGE
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The present invention provides a polymerizable compound denoted by Formula (I): in the formula, Z1 and Z2 represent an arylene group, and the like, m represents 1 or 2, n represents an integer of 0 or 1, and when m is 2, n is 0, Lsu
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Paragraph 0190-0191
(2017/01/31)
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- A process for preparing 1,4-diphenyl cyclohexane dicarboxylate
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The present invention relates to a production method of 1,4-diphenyl cyclohexane dicarboxylate which is usable bio-based polycarbonate. More specifically, the present invention relates to a production method of 1,4-diphenyl cyclohexane dicarboxylate, which is a target material obtained by hydrolyzing 1,4-dimethyl cyclohexane dicarboxylate under acid or base conditions to prepare 1,4-cyclohexane dicarboxylic acid, and making the 1,4-cyclohexane dicarboxylic acid react with phenol through esterification.COPYRIGHT KIPO 2017
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- Novel bivalent securinine mimetics as topoisomerase I inhibitors
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A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.
- Hou, Wen,Lin, Hui,Wang, Zhen-Ya,Banwell, Martin G.,Zeng, Ting,Sun, Ping-Hua,Lin, Jing,Chen, Wei-Min
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p. 320 - 328
(2017/03/08)
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- Unexpected right-handed helical nanostructures co-assembled from l-phenylalanine derivatives and achiral bipyridines
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The construction of chiral supramolecular systems with desirable handedness is of great importance in materials science, chemistry, and biology since chiral nanostructures exhibit fascinating photophysical properties and unique biological effects. Herein,
- Liu, Guofeng,Liu, Jinying,Feng, Chuanliang,Zhao, Yanli
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p. 1769 - 1775
(2017/03/09)
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- 1,4-cyclohexanedicarboxylic acid alkylphosphoramide dichloride production method
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PROBLEM TO BE SOLVED: To produce transparent 1,4-cyclohexanedicarboxylic acid dichloride suppressed in reduction of the ratio of a cis-form from cis-trans mixed 1,4-cyclohexanedicarboxylic acid containing terephthalic acid.SOLUTION: A method for producing
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Paragraph 0035
(2017/06/02)
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- A SMALL MOLECULE INHIBITOR OF MYD88 FOR THERAPEUTIC TREATMENT AGAINST ALPHAVIRUS AND STAPHYLOCOCCAL ENTEROTOXIN INFECTIONS AND TOXIN EXPOSURE
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A synthetic molecule 4210 and a therapeutic use of a synthetic small molecule 4210 for treating viral infections, especially encephalitic alphavirus infections. The compound 4210 showed antiviral efficacy by up regulation type 1 interferon (IFN) specifica
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Page/Page column 7
(2016/01/01)
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- METHOD OF PRODUCING 1,4-CYCLOHEXANE DICARBOXYLIC ACID DICHLORIDE
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PROBLEM TO BE SOLVED: To produce 1,4-cyclohexane carboxylic acid dichloride in a production method that is safe and environmentally friendly without avoiding the excessive use of a chlorinating agent, a reaction solvent, and a catalyst. SOLUTION: This inv
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Paragraph 0035
(2016/10/07)
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- AMIDINE COMPOUND OR SALT THEREOF
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The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida, the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent. A compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof is useful as an anti-fungal agent.
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Paragraph 0382; 0383
(2014/06/23)
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- 5HT1A ANTAGONIST USEFUL FOR IN VIVO IMAGING
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The present invention provides a novel compound of formula (I) useful for in vivo imaging of 5-HT1 A receptors in a subject. Also provided by the present invention is a precursor compound useful in the preparation of the compound of the inventi
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Page/Page column 23; 24; 31
(2013/03/26)
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- NOVEL SYNTHESIS METHOD
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The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT1A. The method of the present invention provides advantages over the known methods of synthesis. The compounds
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Page/Page column 18-19
(2013/04/10)
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- New poly(arylene ether sulfone)s based on 4,4′-[trans-1,4- cyclohexanediylbis(methylene)] bisphenol
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Incorporation of 4,4′-dihydroxy-p-terphenyl (DHTP) and a new bisphenol comonomer, 4,4′-[trans-1,4-cyclohexanediylbis(methylene)] bisphenol (CMB), into a dichlorodiphenyl sulfone (DCDPS) based poly(ether sulfone) resulted in a synergistic effect with an or
- Zhang, Bin,Turner, S. Richard
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p. 4493 - 4500
(2013/08/23)
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- Syntheses, crystal structures, and photoluminescence properties of three bis-acylamide compounds
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Three bis-acylamide compounds, N1,N4-bis(pyridin-4- yl)-cyclohexane-1, 4-dicarboxamide (L1), 1, 1′-(1, 3-phenylenedicarbonyl-) bis(1H-1, 2, 3-benzotriazole) (L2), and N1,N4-bis(1H-1, 2, 4-triazole) phthalamide (L3) were synthesized. L1, L2, and a CuII complex based on L3 formulated as CuCl2(L3)2(en) 2 (1) (en = ethylenediamine) were structurally characterized by single-crystal X-ray diffraction for the first time. L1, L2, and L3 exhibit different photoluminescence properties. Copyright
- Wu, Tao,Gong, Yun,Qin, Jianbo,Wu, Xiaoxia,Cao, Rong
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experimental part
p. 438 - 442
(2012/05/05)
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- Efficient two directional syntheses of a homophthalate ester and novel resorcylate oligomers
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Thermolysis of 6,6′-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3- dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of diethylzinc was used to synthesize other double diketo-dioxinones, which on cyclization, aromatization and dioxinone ring opening gave novel double resorcylate derivatives.
- Patel, Bhavesh H.,Heath, Scott F.A.,Mason, Andrew M.,Barrett, Anthony G.M.
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supporting information; experimental part
p. 2258 - 2261
(2011/05/05)
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- Synthesis and characterization of poly(arylene ether sulfone)s with trans-1,4-cyclohexylene ring containing ester linkages
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trans-1,4-Cyclohexylene ring containing acid chloride monomers were incorporated into poly(arylene ether sulfone) (PAES) backbones to study their effect on mechanical and thermal properties. The trans-1,4-cyclohexylene ring containing acid chloride monome
- Zhang, Bin,Turner, S. Richard
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experimental part
p. 4316 - 4324
(2012/06/01)
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- ORGANIC COMPOUNDS
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The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
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Page/Page column 35
(2009/05/28)
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- Discovery of small molecule CXCR4 antagonists
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In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding assay against the liga
- Zhan, Weiqiang,Liang, Zhongxing,Zhu, Aizhi,Kurtkaya, Serdar,Shim, Hyunsuk,Snyder, James P.,Liotta, Dennis C.
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p. 5655 - 5664
(2008/03/17)
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- Synthesis of C2-Symmetric Compounds via Double Alkylation of (α,ω-Dioxo-alkanediyl)bis-2-oxazolidinone Derivatives
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A series of chiral C2-symmetric compounds was prepared from readily available α,ω-diacyl chlorides and optically pure 2-oxazolidinone derivatives.Following preparation of the asymmetrically pure bis-oxazolidinone derivatives (6a-d, 11, 13, and 20), we pre
- Trova, Michael P.,Wang, Yizhe
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p. 4147 - 4158
(2007/10/02)
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- Reentrant Phases in New Polar Cyclohexane Series
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A homologous series of 4'-alkoxyphenyl 4''-cyanophenyl, 1,4-cyclohexanedicarboxylates in which the alkoxy group is C1 -> C12 has been prepared.Interphase transitions between solid, mesomorphic and isotropic phases were studied by hot stage microscopy.The
- Tinh, Nguyen Huu
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p. 143 - 152
(2007/10/02)
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