131779-79-8

Basic information

• Product Name: CIS-2-(3,4-METHYLENEDIOXYBENZOYL)CYCLOHEXANE-1-CARBOXYLIC ACID
• Synonyms: CIS-2-(3,4-METHYLENEDIOXYBENZOYL)CYCLOHEXANE-1-CARBOXYLIC ACID
• CAS NO: 131779-79-8
• Molecular Formula: C₁₅H₁₆O₅
• Molecular Weight: 276.28
• Mol File: 131779-79-8.mol

Chemical Properties

• Melting Point: 152-154 °C
• Boiling Point: 494.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• PKA: 4.48±0.44(Predicted)
• CAS DataBase Reference: CIS-2-(3,4-METHYLENEDIOXYBENZOYL)CYCLOHEXANE-1-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-2-(3,4-METHYLENEDIOXYBENZOYL)CYCLOHEXANE-1-CARBOXYLIC ACID(131779-79-8)
• EPA Substance Registry System: CIS-2-(3,4-METHYLENEDIOXYBENZOYL)CYCLOHEXANE-1-CARBOXYLIC ACID(131779-79-8)

Safety Data

• Hazardous Substances Data: 131779-79-8(Hazardous Substances Data)

Upstream product

• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 109586-40-5 1,3-dihydroisobenzofuran-5-yl trifluoromethanesulfonate 

Downstream Products

• 131779-82-3 [(1R,2S)-2-(Benzo[1,3]dioxole-5-carbonyl)-cyclohexyl]-carbamic acid tert-butyl ester 
• 131779-88-9 C₂₅H₂₉NO₆S 
• 131779-83-4 N-[(1R,2S)-2-(Benzo[1,3]dioxole-5-carbonyl)-cyclohexyl]-4-methyl-benzenesulfonamide 
• 131779-80-1 N-[(1R,2R)-2-(1-Benzo[1,3]dioxol-5-yl-vinyl)-cyclohexyl]-4-methyl-benzenesulfonamide 
• 131779-81-2 [(1R,2R)-2-(1-Benzo[1,3]dioxol-5-yl-vinyl)-cyclohexyl]-carbamic acid tert-butyl ester 
• 131779-87-8 N-[(1S,2S)-2-(1-Benzo[1,3]dioxol-5-yl-vinyl)-cyclohexyl]-methanesulfonamide 
• 129483-43-8 N-[(1R,2R)-2-((S)-1-Benzo[1,3]dioxol-5-yl-2-hydroxy-ethyl)-cyclohexyl]-4-methyl-benzenesulfonamide 

Relevant articles and documents

Nickel-Catalyzed Desymmetrizing Cross-Electrophile Coupling of Cyclic Meso-Anhydrides

A Ni-catalyzed desymmetrizing cross-electrophile coupling of cyclic meso-anhydrides with aryl triflates has been successfully demonstrated. This is the only example using cyclic meso-anhydrides in cross-electrophile coupling reactions. A diverse array of valuable γ-keto acid building blocks can be generated under these conditions with excellent functional group tolerance and stereochemical fidelity.

Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones

A series of 4-aryl-substituted cis-4a,5,8,8a-tetra- and cis-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-ones with high inhibitory activity toward cAMP-specific phosphodiesterase (PDE4) was synthesized. To study structure-activity relationships various substituents were introduced to the 2-, 3-, and 4-positions of the 4-phenyl ring. Substitution at the 4-position of the phenyl ring was restricted to a methoxy group, probably due to unfavorable steric interactions of larger groups with the binding site. The introduction of many alkoxy substituents including distinct ring systems and functional groups was allowed to the 3-position. It was found that in general the cis-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones are more potent than their hexahydrophthalic counterparts, the best activity residing in (4-imidazol-1-yl-phenoxy)butoxy analogue 16o (pIC50 = 9.7).

A Stereoselective Synthesis of a Basic Skeleton of Amaryllidaceae Montanine-type Alkaloids, (+/-)-4a,11a-cis-11,11a-syn-5,11-Methanomorphanthridine Ring System

A title compound was synthesized by reductive cyclization of 4a,11a-cis-11,11a-syn-11-acetoxymethyl-N-p-tosylmorphanthridine or N-detosylated alcohol derived from a hydroxymethyl-p-tosylamide prepared by hydroboration-oxidation of cis-1-(p-tosylamido)-2-v