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131865-53-7

N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 131865-53-7 Structure

  • Basic information

    1. Product Name: N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate
    2. Synonyms: N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate
    3. CAS NO:131865-53-7
    4. Molecular Formula: C19H23 F N2 O5
    5. Molecular Weight: 378.39
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 131865-53-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.27g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 15?+-.0.46(Predicted)
    10. CAS DataBase Reference: N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate(131865-53-7)
    12. EPA Substance Registry System: N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate(131865-53-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 131865-53-7(Hazardous Substances Data)

131865-53-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 131865-53-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,8,6 and 5 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 131865-53:
(8*1)+(7*3)+(6*1)+(5*8)+(4*6)+(3*5)+(2*5)+(1*3)=127
127 % 10 = 7
So 131865-53-7 is a valid CAS Registry Number.

131865-53-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,5-dioxopyrrolidin-1-yl) 8-[(4-fluorophenyl)methylamino]-8-oxooctanoate

1.2 Other means of identification

Product number -
Other names SFBS

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:131865-53-7 SDS

131865-53-7Downstream Products

131865-53-7Relevant articles and documents

Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma

Keller, Max,Maschauer, Simone,Brennauer, Albert,Tripal, Philipp,Koglin, Norman,Dittrich, Ralf,Bernhardt, Günther,Kuwert, Torsten,Wester, Hans-Jürgen,Buschauer, Armin,Prante, Olaf

supporting information, p. 304 - 309 (2017/03/17)

The neuropeptide Y (NPY) Y1 receptor (Y1R) selective radioligand (R)-Nα-(2,2-diphenylacetyl)-Nω-[4-(2-[18F]fluoropropanoylamino)butyl]aminocarbonyl-N-(4-hydroxybenzyl)argininamide ([18F]23), derived from the high-affinity Y1R antagonist BIBP3226, was developed for imaging studies of Y1R-positive tumors. Starting from the argininamide core bearing amine-functionalized spacer moieties, a series of fluoropropanoylated and fluorobenzoylated derivatives was synthesized and studied for Y1R affinity. The fluoropropanoylated derivative 23 displayed high affinity (Ki = 1.3 nM) and selectivity toward Y1R. Radiosynthesis was accomplished via 18F-fluoropropanoylation, yielding [18F]23 with excellent stability in mice; however, the biodistribution study revealed pronounced hepatobiliary clearance with high accumulation in the gall bladder (>100 %ID/g). Despite the unfavorable biodistribution, [18F]23 was successfully used for imaging of Y1R positive MCF-7 tumors in nude mice. Therefore, we suggest [18F]23 as a lead for the design of PET ligands with optimized physicochemical properties resulting in more favorable biodistribution and higher Y1R-dependent enrichment in mammary carcinoma.

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