131942-82-0

Basic information

• Product Name: N-(4-methoxyphenyl)-2-({5-[(4-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
• Synonyms: N-(4-methoxyphenyl)-2-({5-[(4-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
• CAS NO: 131942-82-0
• Molecular Formula: C₂₅H₂₄N₄O₃S
• Molecular Weight: 460.54806
• Mol File: 131942-82-0.mol

Chemical Properties

• Melting Point: 184-185 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5); ethanol (64-17-5))
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: 12.34±0.70(Predicted)
• CAS DataBase Reference: N-(4-methoxyphenyl)-2-({5-[(4-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-2-({5-[(4-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide(131942-82-0)
• EPA Substance Registry System: N-(4-methoxyphenyl)-2-({5-[(4-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide(131942-82-0)

Safety Data

• Hazardous Substances Data: 131942-82-0(Hazardous Substances Data)

Upstream product

• 76111-27-8 5-[(4-methylphenoxy)methyl]-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 76111-27-8 4-Phenyl-5-p-tolyloxymethyl-4H-[1,2,4]triazole-3-thiol 

Relevant articles and documents

Synthesis and bioactivity of some new [3-[4-methylphenoxymethyl]-4-phenyl- [1,2,4]-triazole-5-thio]acetanilide derivatives

The synthesis of some triazole derivatives starting from 4-methyl-phenoloxyacetyl hydrazide is described. In this process, the method for the synthesis of 2-chloroacetanilide had been improved and good yields have been obtained. The chemical structure of

SYNTHESIS OF SOME NEW 3-ARYLOXYMETHYL-4-PHENYL-5-(N-SUBSTITUTED CARBOXYAMIDOMETHYL THIO)-s-TRIAZOLES

3-Aryloxymethyl-4-phenyl-5-mercapto-s-triazoles (1a-c) have been synthesized and reacted with N-chloroacetyl derivatives of aromatic and/or heterocyclic amines to yield 5-(N-aryl/heterocyclyl)-carboxamidomethyl thio-s-triazole derivatives 2a-u and 3a-i respectively.Reaction of 1a-c with ethyl chloroacetate gave the corresponding esters 4a-c which were reacted with hydrazine hydrate to give hydrazides 5a-c.Condensation of 5a-c with aromatic aldehydes gave Schiff's bases 6a-u which on cycloaddition reaction with thioglycolic acid yielded 4-thiazolidinones 7a-g.Some of these compounds were screened in vitro for their antibacterial activities.