132077-74-8

Basic information

• Product Name: Aids000431
• Synonyms: 2,3-Oxetanedimethanol, 4-(6-amino-9H-purin-9-yl)-, (2alpha,3beta,4alpha)-2-amino-9-(2-deoxy-2-hydroxymethyl-.beta.-D-erythro-oxetanosyl)adenosine;2-Amino-9-(2-deoxy-2-hydroxymethyl-.beta.-D-erythro-oxetanosyl)adenosine;2-Amino-oxt-a;Aids000431;Aids-000431
• CAS NO: 132077-74-8
• Molecular Formula: C10H14N6O3
• Molecular Weight: 266.25656
• Mol File: 132077-74-8.mol

Chemical Properties

• Boiling Point: 720.8°Cat760mmHg
• Flash Point: 389.7°C
• Appearance: /
• Density: 2.08g/cm³
• Vapor Pressure: 8.32E-22mmHg at 25°C
• Refractive Index: 1.935
• CAS DataBase Reference: Aids000431(CAS DataBase Reference)
• NIST Chemistry Reference: Aids000431(132077-74-8)
• EPA Substance Registry System: Aids000431(132077-74-8)

Safety Data

• Hazardous Substances Data: 132077-74-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14N6O3/c11-7-6-8(15-10(12)14-7)16(3-13-6)9-4(1-17)5(2-18)19-9/h3-5,9,17-18H,1-2H2,(H4,11,12,14,15)/t4-,5-,9-/m1/s1

Upstream product

• 132454-58-1 N-[9-((2R,3R,4S)-3,4-Bis-benzyloxymethyl-oxetan-2-yl)-9H-purin-6-yl]-benzamide 
• 121885-21-0 Oxetanocin A N⁶-benzoate 
• 120188-06-9 C₃₈H₂₉N₅O₇ 
• 117068-56-1 9-((2' R,3' R,4' S)-3'-hydroxymethyl-4'-(t-butyldimethylsilyloxymethyl)-2'-oxetanyl)adenine 
• 117068-55-0 N₆-benzoyl-9-((2' R,3' R,4' S)-3'-methoxycarbonyl-4'-(t-butyldimethylsilyloxymethyl)-2'-oxetanyl)adenine 
• 120188-05-8 Oxalic acid (2S,3R,4S)-2-acetoxy-4-propionyloxymethyl-oxetan-3-ylmethyl ester methyl ester 
• 120293-58-5 (2α, 3α, 4β)-2-acetoxy-3-carbomethoxycarbonyloxymethyl-4-propionyloxymethyloxetane 
• 114406-09-6 9-(2-oxetanyl)adenine 
• 115043-32-8 N-{9-[(2R,3R,4R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-vinyl-oxetan-2-yl]-9H-purin-6-yl}-benzamide 
• 115043-33-9 N-{9-[(2R,3R,4S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-formyl-oxetan-2-yl]-9H-purin-6-yl}-benzamide 
• 115043-34-0 N-{9-[(2R,3R,4S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxymethyl-oxetan-2-yl]-9H-purin-6-yl}-benzamide 
• 69832-48-0 ((3aR,5S,6R,6aR)-tetrahydro-2,2-dimethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)furo[2,3-d][1,3]dioxol-6-yl)methanol 
• 69827-89-0 ((3aR,5S,6R,6aR)-5-Hydroxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl)-methanol 
• 26277-33-8 (R)-1-((3aR,5S,6R,6aR)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethane-1,2-diol 

Downstream Products

• 121885-21-0 Oxetanocin A N⁶-benzoate 

Relevant articles and documents

Synthesis of L-Oxetanocin

matrix presented Hitherto unknown L-oxetanocin has been synthesized from L-xylose in 16 steps via a ribonolactone derivative.

Analogs of oxetanyl purines and pyrimidines

A compound of the formula: STR1 wherein B is a purin-9-yl group or a heterocyclic isostere of a purin-9-yl group; or a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; A is --CH-- or A--G taken together is --C(=O)--, --C(=CH

SYNTHESIS OF OXETANOCIN

A low yield synthesis of oxetanocin and its α-epimer by reaction of adenine with a protected 3-hydroxymethyl-2-chlorooxetane is described; attempts to synthesise other C-2'alkyl analogues of oxetanocin by analogous reactions indicate a limitation of this strategy for the synthesis of oxetane nucleosides.An intermediate for the synthesis of C-nucleoside analogues of oxetanocin is reported.

Oxetane derivatives

The present invention relates to an oxetane derivative represented by the general formula (I): STR1 wherein R1 and R2 are each an acyl group and R3 is a hydrogen atom or a lower alkyl group, which is useful as an intermediate for the preparation of a compound having a (bishydroxymethyl)oxetane structure in its saccharide moiety, for example, oxetanosine, and a process for the preparation of the same.

A TOTAL SYNTHESIS OF OXETANOCIN, A NOVEL NUCLEOSIDE WITH AN OXETANE RING

Oxetanocin has been synthesized starting from cis-2-buten-1,4-diol through α- or β-D-oxetanosyl acetate as an important intermediate which has an α-(methyl oxalyloxy)methyl group at C2-position.