HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF N-BOC DOLAISOLEUINE, UNUSUAL AMINO ACID IN DOLASTATIN 10
Photolysis of 5-phenylthiooxazolidin-2-one (4) in the presence of (n-Bu3Sn)2 and n-Bu3SnCH2CH=CH2 afforded 5-allyl derivative (5) which was led to N-Boc dolaisoleuine (11), one component of dolastatine 10 (2), via 6-10.
Kano, Shinzo,Yuasa, Yoko,Shibuya, Shiroshi
p. 1597 - 1600
(2007/10/02)
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