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2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a pyridine derivative featuring a bromine atom and a boronic ester functional group. This chemical compound is pivotal in organic synthesis, particularly for its role in the Suzuki-Miyaura cross-coupling reaction, a method renowned for forming carbon-carbon bonds. The presence of the boronic ester group in this compound facilitates selective and efficient coupling with a range of aryl and vinyl halides, thereby enhancing its value in the construction of complex organic molecules. The bromine substituent further augments its utility by offering opportunities for additional functionalization and chemical manipulations.

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  • 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

    Cas No: 1321518-06-2

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  • 1321518-06-2 Structure
  • Basic information

    1. Product Name: 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
    2. Synonyms: 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-Bromo-6-methylpyridine-4-boronic acid, pinacol ester;2-bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methylpyridine
    3. CAS NO:1321518-06-2
    4. Molecular Formula: C12H17BBrNO2
    5. Molecular Weight: 297.98388
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1321518-06-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(1321518-06-2)
    11. EPA Substance Registry System: 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(1321518-06-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1321518-06-2(Hazardous Substances Data)

1321518-06-2 Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique structure allows for the creation of diverse drug candidates with potential therapeutic applications, leveraging the compound's reactivity in cross-coupling reactions to introduce novel functionalities into drug molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine serves as a key building block for the assembly of complex organic molecules. Its ability to participate in Suzuki-Miyaura cross-coupling reactions enables chemists to construct intricate molecular architectures with precision, contributing to the advancement of materials science and the discovery of new chemical entities.
Used in Chemical Research:
2-Bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is utilized as a research tool in academic and industrial laboratories. Its involvement in cross-coupling reactions provides insights into reaction mechanisms, catalyst development, and the exploration of new synthetic methodologies, thereby advancing the frontiers of chemical science.

Check Digit Verification of cas no

The CAS Registry Mumber 1321518-06-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,2,1,5,1 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1321518-06:
(9*1)+(8*3)+(7*2)+(6*1)+(5*5)+(4*1)+(3*8)+(2*0)+(1*6)=112
112 % 10 = 2
So 1321518-06-2 is a valid CAS Registry Number.

1321518-06-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

1.2 Other means of identification

Product number -
Other names 2-BROMO-6-METHYLPYRIDINE-4-BORONIC ACID,PINACOL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1321518-06-2 SDS

1321518-06-2Upstream product

1321518-06-2Downstream Products

1321518-06-2Relevant articles and documents

1,2,4-TRIAZINE-4-AMINE DERIVATIVES

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Page/Page column 116, (2011/09/14)

According to the invention there is provided a compound of formula A1 which may be useful in the treatment of a condition or disorder ameliorated by the inhibition of the A1- A2b or, particularly, the A2a receptor wherein the compound of formula A1 has the structure, wherein, A represents Cy1 or HetA; Cy1 represents a 5- to 14-membered aromatic, fully saturated or partially unsaturated carbocyclic ring system comprising one, two or three rings, which Cy1 group is optionally substituted by one or more R4a substituents; HetA represents a 5- to 14-membered heterocyclic group that may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from O, S and N, which heterocyclic group may comprise one, two or three rings and which HetA group is optionally substituted by one or more R4b substituents; B represents a Cy2 or HetB; Cy2 represents a 3- to 10-membered aromatic, fully saturated or partially unsaturated carbocyclic ring system comprising one or two rings, which Cy2 group is optionally substituted by one or more R4c substituents; HetB represents a 3- to 10-membered heterocyclic group that may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from O, S and N, which heterocyclic group may comprise one or two rings and which HetB group is optionally substituted by one or more R4d substituents.

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