Antimycobacterial Activity of a Series of Pyrazinoic Acid Esters
A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity.Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptible isolates of Mycobacterium tuberculosis as well as activity against pyrazinamide-resistant isolates.The minimal inhibitory concentrations (MICs) were lower for each organism and at each pH than the MICs for pyrazinamide.The esters have activity against Mycobacterium bovis and Mycobacterium kansasii, two species resistant to pyrazinamide, but not against Mycobacterium avium complex.
Cynamon, Michael H.,Klemens, Sally P.,Chou, Tso-Sheng,Gimi, Rayomand H.,Welch, John T.
p. 1212 - 1215
(2007/10/02)
Pyrazinoic acid esters as antituberculosis agents
Pyrazinoic esters have been prepared. Compounds of this group are effective against mycobacteria including Mycobacteria tuberculosis, pyrazinamide-resistant Mycobacteria tuberculosis, Mycobacteria bovis and Mycobacteria kansasii.
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(2008/06/13)
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