Synthesis, Resolution, and SAR of (+/-)-2-Amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine and Related Analogs as Noncompetitive NMDA Antagonists with Neuroprotective Properties
The preparation and structure-activity relationships of a series of 2-amino-α-thienylbenzeneethanamines are described.From this work, (+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)-benzeneethanamine (3a) and the homologous N-ethyl analog 3b emerged as nove
Martin, Lawrence L.,Lee, George E.,Lee, Thomas B. K.,Rush, Douglas K.,Wilmot, Carole A.,et al.