- Synthesis and structure - Activity-relationships of 1H-imidazo[4,5-c] quinolines that induce interferon production
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1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.
- Gerster, John F.,Lindstrom, Kyle J.,Miller, Richard L.,Tomai, Mark A.,Birmachu, Woubalem,Bomersine, Shannon N.,Gibson, Shiela J.,Imbertson, Linda M.,Jacobson, Joel R.,Knafla, Roy T.,Maye, Peter V.,Nikolaides, Nickolas,Oneyemi, Folakemi Y.,Parkhurst, Gwen J.,Pecore, Sharon E.,Reiter, Michael J.,Scribner, Lisa S.,Testerman, Tracy L.,Thompson, Natalie J.,Wagner, Tammy L.,Weeks, Charles E.,Andre, Jean-Denis,Lagain, Daniel,Bastard, Yvon,Lupu, Michel
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p. 3481 - 3491
(2007/10/03)
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- 1H-imidazo?4,5-c!quinolin-4-amines
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Novel 1H-imidazo?4,5-c!quinolin-4-amines are disclosed. The compounds function as antiviral agents and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. Processes for the preparation of the compounds, methods for their antiviral use, and methods of inducing interferon biosynthesis, are also described.
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- 1H-Imidazoquinolin-4-amines: Novel Non-Xanthine Adenosine Antagonists
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On the basis of a model we recently developed for the antagonist binding site of the adenosine A1 receptor (J.Med.Chem. 1990, 33, 1708-1713), it was predicted that 1H-imidazoquinolin-4-amines would be antagonists of the A1 rec
- Galen, Philip J. M. van,Nissen, Peter,Wijngaarden, Ineke van,IJzerman, Adriaan P.,Soudijn, Willem
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p. 1202 - 1206
(2007/10/02)
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- Olefinic 1H-imidazo[4,5-c]quinolin-4-amines
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Novel 1-substituted 1H-imidazo-[4,5-c]quinolin-4-amines are disclosed. These compounds function as antiviral agents, and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. This inven
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