Syntheses and Transformations of 2,6-Epoxy-4H-3-benzoxocin-4-ones
Four variations for the preparation of 5 are described: acid-catalyzed cyclisation of the methoxy acid 4a, base-catalyzed lactonisation of the hydroxy ester 6b, DCC-mediated dehydration of the hydroxy acid 6a and PCC oxidation of the hemiacetals 17a and 1
Wuensch, Bernhard,Bauschke, Gerd
p. 345 - 350
(2007/10/02)
A NEW HETEROCYCLE WITH ANALGESIC ACTIVITY: 2,6-EPOXY-1,2,3,4,5,6-HEXAHYDRO-3-METHYL-3-BENZAZOCINE
The title compound (4) was prepared in five steps, starting with the benzaldehyde derivative (5).In the mouse writhing-test 4 showed strong analgesic activity.
Wuensch, Bernhard,Hoefner, Georg,Bauschke, Gerd
p. 1427 - 1429
(2007/10/02)
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