Diastereoselektive Hydroxyalkylierungen in 1-Stellung von Tetrahydroisochinolinen und Synthese von Aporphin-, Protoberberin- und Phthalid-Alkaloiden
Unsubstituted and 6,7-dialkyloxy-N-pivaloyl-tetrahydroisoquinolines 1-3 are converted to 1-bromomagnesium derivatives by sequential treatment with t-BuLi (-75 deg C/THF) and MgBr2*OEt2.Addition of the metalated tetrahydroisoquinolines to aliphatic or arom
Seebach,Dieter,Huber, Isabelle M. P.,Syfrig, Max A.