Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride
We present a simple and straightforward protocol for hydrochlorination of terminal arylalkynes to vinyl chlorides using hydrogen chloride under mild reaction conditions. This protocol does not involve any metal catalysts or additives. It is simple, inexpensive, and easy to prepare, and exhibits good reaction activity. The hydrochlorination proceeds smoothly to yield unique regioselective products via the Markovnikov addition rule.
Xu, Cai-Xia,Ma, Cun-Hua,Xiao, Fu-Rong,Chen, Hong-Wei,Dai, Bin
MOLECULES FOR INTRAMOLECULAR RECOGNITION. SYNTHESIS AND STRUCTURES OF DIARYL- AND ARYLNAPHTHYLETHYNES
While synthesizing models for intramolecular recognition, a simple and efficient method for forming terminal arylethynes was developed and palladium-catalyzed coupling chemistry of alkynes with either aryl iodides or aryl triflates was used to form crowde
Evans, Kevin L.,Prince, Philippe,Huang, Enoch T.,Boss, Keisha R.,Gandour, Richard D.
p. 6753 - 6756
(2007/10/02)
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