ASYMMETRIC SYNTHESIS OF (+)- AND (-)-CONIINES AND (-)-SEDAMINE BY DIASTEREOSELECTIVE ALKYLATION REACTION OF ETHOXYPIPERIDININE
Diastereoselective alkylation reaction of the chiral 6-ethoxypiperidinones (4) and (5) has been developed and successfully applied to the asymmetric synthesis of piperidine alkaloids, (+)- and (-)-coiines (11) and (12), (-)-sedamine (21), and (-)-allosedamine (22).