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132414-02-9

2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride, also known as alosetron, is a potent and selective 5-HT3 antagonist. It is a structurally-related analog of ondansetron and is prepared by alkylation of the pyrido[4,3-b]indol-1-one skeleton with the appropriate trityl-protected chloromethylimidazole. Alosetron has a superior pharmacodynamic profile than ondansetron and is used as an oral treatment for diarrhea-predominant irritable bowel syndrome (IBS) in women.
Used in Pharmaceutical Industry:
2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride is used as a therapeutic agent for the treatment of diarrhea-predominant irritable bowel syndrome (IBS) in women. It acts as a potent and selective 5-HT3 antagonist, which helps regulate intestinal secretion, gastrointestinal contractility, and gastric emptying. Clinically, it has been found to improve bowel function, stool frequency, and stool consistency, as well as affect pain severity and the sense of urgency in IBS patients.

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  • 132414-02-9 Structure

  • Basic information

    1. Product Name: 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride
    2. Synonyms: Alosetron (Hydrochloride) (1:X)
    3. CAS NO:132414-02-9
    4. Molecular Formula: C17H18N4O.x(HCl)
    5. Molecular Weight: 330.81196
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 132414-02-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride(132414-02-9)
    11. EPA Substance Registry System: 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride(132414-02-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 132414-02-9(Hazardous Substances Data)

132414-02-9 Usage

Originator

Glaxo-Wellcome (UK)

Biological Activity

Alosetron(GR68755)Hydrochloride(1:X) is a potent and selective 5-HT3 receptor (5-HT3receptor) antagonist. AlosetronHydrochloride(1:X) for the study of irritable bowel syndrome (IBS). AlookchemlosetronHydrochloride (1:X) blocks 5HT3-mediated rapid depolarization of guinea pig intermuscular and submucosal neurons with IC50 at ~55nM. AlosetronHydrochloride (1:X) attenuates visceral nociceptive effects of rectal distension in awake or anesthetized dogs. Has anti-inflammatory activity.

in vivo

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis.

Check Digit Verification of cas no

The CAS Registry Mumber 132414-02-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,1 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 132414-02:
(8*1)+(7*3)+(6*2)+(5*4)+(4*1)+(3*4)+(2*0)+(1*2)=79
79 % 10 = 9
So 132414-02-9 is a valid CAS Registry Number.

132414-02-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one,hydrochloride

1.2 Other means of identification

Product number -
Other names UNII-2F5R1A46YW

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132414-02-9 SDS

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