132434-55-0

Basic information

• Product Name: (2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one
• Synonyms: (2E)-3-(2-Furyl)-1-(3-nitrophenyl)prop-2-en-1-one; 2-propen-1-one, 3-(2-furanyl)-1-(3-nitrophenyl)-, (2E)-
• CAS NO: 132434-55-0
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.2149
• Mol File: 132434-55-0.mol

Chemical Properties

• Boiling Point: 400.2°C at 760 mmHg
• Flash Point: 195.8°C
• Density: 1.318g/cm³
• Vapor Pressure: 1.29E-06mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: (2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one(132434-55-0)
• EPA Substance Registry System: (2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one(132434-55-0)

Safety Data

• Hazardous Substances Data: 132434-55-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one is used as a reactant in organic synthesis for the creation of other compounds. Its unique molecular structure, which includes a furan ring and a nitrophenyl group, makes it suitable for a variety of chemical reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one is used as a starting material for the synthesis of various drugs. Its structural components allow for the development of new medicinal compounds with potential therapeutic applications.
Safety Measures:
It is important to handle (2E)-3-furan-2-yl-1-(3-nitrophenyl)prop-2-en-1-one with proper safety measures due to its potential hazards. As with any chemical compound, appropriate precautions should be taken to minimize risks during its use and storage.

Upstream product

• 98-01-1 furfural 
• 121-89-1 3-Nitroacetophenone 

Downstream Products

• 82613-30-7 4-Furan-2-yl-2-(3-nitro-phenyl)-6-phenyl-pyridine 

Relevant articles and documents

Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.

Screening of biological activities of a series of chalcone derivatives against human pathogenic microorganisms

In an effort to develop new antimicrobial agents, a series of chalcone derivatives, 3-60, were prepared by Claisen-Schmidt condensation of appropriate acetophenones and 2-furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene-2-carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR- and NMR-spectral data, and elemental analysis. All compounds were tested for their antibacterial and antifungal activities by the disc diffusion method. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.

Ultrasound promoted synthesis of α,α'-bis(substituted furfurylidene) cycloalkanones and chalcones

Condensation of furfural with cycloalkanones and substituted acetophenones catalysed by potassium hydroxide results α,α'- bis(substituted furfurylidene) cycloalkanones and chalcones in high yield under ultrasound irradiation in 4-50 min.