Columnar Stacking of Partially Fluorinated [4]Helicenes: C?H???F Interactions Change the Stacking Orientation
The partial fluorination of polycyclic aromatic hydrocarbons often produces a layered crystal packing, where fluorinated aromatic surfaces are stacked over nonfluorinated aromatic surfaces. Herein, we report the synthesis and crystal packing of partially fluorinated [4]helicenes with steric congestion resulting from H and F atoms in the fjord region. F6-[4]Helicene forms head-to-tail columnar stacks consisting of an alternate arrangement of perfluorinated and nonfluorinated naphthalene moieties. With decreasing fluorine content, aromatic stacking switched from arene?fluoroarene (ArH?ArF) hetero-stacking to ArH?ArH/ArF?ArF homo-stacking with the help of intermolecular C?H???F contacts in the fjord region. As a result, head-to-head columnar stacks appear. Therefore, the conventional ArH?ArF stacking motif is not always applicable to Fn-[4]helicenes with twisted π-surfaces.
Facile synthesis of a series of non-symmetric thioethers including a benzothiazole moiety and their use as effcient in vitro anti-trypanosoma cruzi agents
A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives were synthesized and fully characterized and in vitro tested against two strains of T. cruzi (NINOA and INC-5), exhibiting good activities at low concentrations.
Avila-Sorrosa, Alcives,Tapia-Alvarado, Jazz D.,Nogueda-Torres, Benjamín,Chacón-Vargas, Karla Fabiola,Díaz-Cedillo, Francisco,Vargas-Díaz, María Elena,Morales-Morales, David
(2019/09/03)
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