A new, facile preparation of enamines was achieved via a two-step sequence: (i) the ready formation of an N-(α-aminoalkyl)benzotriazole derivative from equimolar amounts of benzotriazole, an aldehyde, and a secondary amine, (ii) the elimination of benzotriazole from the derivative by sodium hydride in tetrahydrofuran (THF).The method provides enamines in good yields based on the quantity of amine used.
Katritzky, Alan R.,Long, Qiu-He,Lue, Ping,Jozwiak, Andrzej
p. 8153 - 8160
(2007/10/02)
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