- NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
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Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
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- COMPOUNDS SUITABLE FOR USE IN INKS AND INKS HAVING SUCH COMPOUNDS
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Disclosed herein are amide compounds suitable for use in ink compositions, and methods of making the amide compounds disclosed herein.
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- New lyotropic phases (thermally-reversible organogels) of simple tertiary amines and related tertiary and quaternary ammonium halide salts
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Small concentrations of some structurally simple tertiary amines and related tertiary and quaternary ammonium halide salts form viscoelastic, thermally reversible gels with a wide variety of organic liquids.
- Lu, Liangde,Weiss, Richard G.
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p. 2029 - 2030
(2007/10/03)
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- A Hydrolytic Reporter of Cu(II) Availability in Artificial Liposomes
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The dioctadecyl ammonium surfactant 1, functionalized with a p-nitrophenyl ester of picolinic acid has been synthesized and its hydrolysis in covesicular blends of nonfunctional surfactants dihexadecyldimethylammonium bromide, 3, dioctadecyldimethylammonium bromide, 4, and racemic 1,2-bis(palmitoyloxy)-3-(trimethylammonium)propyl bromide, 5, studied after addition of Cu(II) ions pH=5.0 and different temperatures.The cleavage of 1 gives the p-nitrophenoxide surfactant 2, which shows a strong absorption band at 400 nm.Clear biphasic kinetics were observed for all vesicular systems at a temperature below the gel-liquid crystal phase transition temperature (Tc) of the membrane; the first, faster process (ca. 60percent ester cleaved) was associated with the Cu(II)-catalyzed hydrolysis of the exovesicular ester; the slower one (the remaining ca. 40percent of the ester cleaved) was associated with the uncatalyzed hydrolysis of the endovesicular ester.Above Tc only a monoexponential process was observed.Variable temperature experiments allowed one to conclude that the cationic vesicles studied are totally impermeable to Cu(II) ions either below or above their Tc which controls the rate of the transbilayer movements of the lipids.
- Ghirlanda, Giovanna,Scrimin, Paolo,Tecilla, Paolo,Tonellato, Umberto
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p. 3025 - 3029
(2007/10/02)
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