132838-14-3

Basic information

• Product Name: 2-(2-FLUOROETHOXY)-BENZALDEHYDE
• Synonyms: 2-(2-FLUOROETHOXY)-BENZALDEHYDE
• CAS NO: 132838-14-3
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.16
• Mol File: 132838-14-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-FLUOROETHOXY)-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUOROETHOXY)-BENZALDEHYDE(132838-14-3)
• EPA Substance Registry System: 2-(2-FLUOROETHOXY)-BENZALDEHYDE(132838-14-3)

Safety Data

• Hazardous Substances Data: 132838-14-3(Hazardous Substances Data)

Usage

Clear, colorless liquid

This describes the physical appearance of the compound, which is a transparent and colorless liquid.

Slightly sweet odor

This describes the smell of the compound, which is slightly sweet.

Used as an intermediate in the synthesis of various pharmaceuticals and organic compounds

This describes one of the main uses of the compound, which is as a starting material or building block in the production of other chemicals, including drugs and other organic compounds.

Utilized in the manufacturing of dyes, perfumes, and other chemical products

This describes another use of the compound, which is in the production of various consumer products, such as dyes and perfumes.

Role in the production of various chemical derivatives

This describes the ability of the compound to be modified or transformed into other related compounds, which can have different properties and uses.

Handle with care and follow proper safety protocols

This is a warning to handle the compound with care and follow proper safety protocols, as it can be harmful if ingested, inhaled, or comes into contact with skin and eyes.

Upstream product

• 22042-72-4 2-(2-hydroxyethoxy)benzaldehyde 
• 383-50-6 2-fluoroethyl tosylate 
• 90-02-8 salicylaldehyde 

Relevant articles and documents

Synthesis and evaluation of antiplasmodial activity of 2,2,2-trifluoroethoxychalcones and 2-fluoroethoxy chalcones against plasmodium falciparum in culture

A new class of compounds comprising two series of chalcones with 2,2,2-trifluoroethoxy group and 2-fluoroethoxy groups were synthesized and screened for in vitro antiplasmodial activity against Plasmodium falciparum (3D7) using the [3H] hypoxanthine incorporation inhibition assay. Chalcones with 2,2,2-trifluoroethoxy groups substituted on the p- and m-positions of the 1-phenyl ring showed weak antiplasmodial activity, while compounds substituted on the o-position of the 1-phenyl ring displayed enhanced antiplasmodial activity, thus indicating that 2,2,2-trifluoroethoxy groups on the 1-phenyl ring of chalcones show position-dependent antiplasmodial activity. Of the 34 compounds synthesized, chalcones 3a and 3f exhibited significant inhibitory effects, with IC50 values of 3.0 μg/mL and 2.2 μg/mL, respectively. Moreover, these compounds 3a and 3f showed profound antiplasmodial activity in combination with artemisinin in vitro. The most active molecules, 3a, and 3f, were further assessed for their cytotoxicity towards mammalian Vero cells and the selectivity index (SI) values are 8.6, and 8.2 respectively, being considered non-toxic. We also studied the antiplasmodial activity of 2-fluoroethoxychalcones to discern the effect of the number of fluorine atoms in the fluoroethoxy group. Our results showed that chalcones with 2-fluoroethoxy group on the 1-phenyl ring exhibited more enhanced inhibitory effects on the growth of parasites than their trifluoro analogues, which reveals that monofluoroethoxy group is generally more effective than trifluoroethoxy group in the inhibition of parasite growth. Thus o-2,2,2-trifluoroethoxychalcones (Series 3) and 2-fluoroethoxychalcones may serve as good antiplasmodial candidates for future further development.

Direct and convenient conversion of alcohols to fluorides

Directly mixing primary, secondary, and tertiary alcohols with nC 4F9SO2F-NR3(HF)3-NR 3 in THF or MeCN results in convenient conversion to the corresponding fluorides in high yields. The readily available reagents are easy to handle, and the mild, almost neutral reaction conditions allow for excellent functional group compatibility. A NR3(HF)3/NR3 ratio of ≤ 1:2 gives the highest reactivity.