REGIO- AND STEREOSELECTIVE CONTROL IN THE ALKYLATION OF 1-ALKOXY-1,4-CYCLOHEXADIENES BY THE CHIRAL AUXILIARY APPROACH. ENANTIOSELECTIVE SYNTHESIS OF PRECURSORS FOR CIS-HYDRINDANES.
A method is described for the regio- and diastereoselective alkylation of optically active 1-alkoxy-1,4-cyclohexadienes.Reaction conditions were optimised for substrates 4a with the per-O-methyl-β-D-glucopyranosyl group as chiral auxiliary.In the methylat